Jama Clinical Reviews: Interviews About Ideas & Innovations In Medicine, Science & Clinical Practice. Listen & Earn Cme Credi

The 2021 US maternal mortality rate is more than 10 times the rate of other high-income countries, according to a March 2023 CDC report. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, is joined by Monica McLemore, PhD, MPH, RN, University of Washington, Audra Meadows, MD, MPH, UC San Diego, and Joia Crear-Perry, MD, founder and president of the National Birth Equity Collaborative, to discuss these concerning numbers and why preventable death rates are worsening in the US. Related Content: Trends in State-Level Maternal Mortality by Racial and Ethnic Group in the United States Worsening US Maternal Death Rates US Maternal Mortality Is Unacceptably High, Unequal, and Getting Worse—What Can Be Done About It? Trends in Maternal Mortality and Severe Maternal Morbidity During Delivery-Related Hospitalizations in the United States, 2008 to 2021

Interview with Michael Silverstein, MD, MPH, USPSTF chair and coauthor of Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Anxiety Screening Depression and Suicide Risk Screening Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Are There Reasons to Fear Anxiety Screening? Reframing the Key Questions Regarding Screening for Suicide Risk

JAMA Senior Editor Kristin Walter, MD, MS, speaks with Fernando Zampieri, MD, PhD, assistant professor in the Department of Critical Care Medicine at the University of Alberta in Alberta, Canada, about fluid therapy in critically ill adults with sepsis. Related Content: Fluid Therapy for Critically Ill Adults With Sepsis

Transgender and gender diverse persons may desire gender-affirming medical and surgical treatment that can mitigate psychologic distress and reduce suicide risk. JAMA Associate Editor David L. Simel, MD, MHS, speaks with Andrew M. Davis, MD, MPH, University of Chicago, and Tonia Poteat, PhD, PA-C, MPH, University of North Carolina, Chapel Hill, about the Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 guidelines. Related Content: Standards of Care for Transgender and Gender Diverse People

Cirrhosis affects approximately 2.2 million adults in the US, and the annual age-adjusted mortality of cirrhosis has increased from 2010 to 2021. JAMA Senior Editor Karen E. Lasser, MD, MPH, and Elliot B. Tapper, MD, from the University of Michigan, discuss the diagnostic workup and evidence-based therapies for cirrhosis. Related Content: Diagnosis and Management of Cirrhosis and Its Complications

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis Infection Among Non–US-Born Adults in the US Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Skin Cancer Screening Screening and Prevention of Skin Cancer Screening for Skin Cancer What Is Mohs Surgery? Skin Cancer Screening

One in 3 adults in the US has prediabetes. JAMA Associate Editor David L. Simel, MD, interviews Samuel Dagogo-Jack, MD, who is the chief of the Division of Endocrinology, Diabetes, and Metabolism at the University of Tennessee, about the diagnosis, screening, complications, lifestyle interventions, and medications for prediabetes. Related Content: Diagnosis and Management of Prediabetes

Chronic lymphocytic leukemia (CLL) affects more than 200 000 people and is associated with >4000 deaths in the US annually. Many people have asymptomatic disease and can be monitored without treatment for long periods. In this podcast, author Mazyar Shadman, MD, MPH, from the University of Washington, Seattle, joins JAMA Deputy Editor Mary M. McDermott, MD, in a discussion about diagnosis and management of CLL. Related Content: Diagnosis and Treatment of Chronic Lymphocytic Leukemia

Approximately 3 million people in the US have heart failure with preserved ejection fraction (HFpEF). JAMA Executive Editor Gregory Curfman, MD, discusses diagnosis and treatment of HFpEF with authors Margaret Redfield, MD, and Barry Borlaug, MD, both from Mayo Foundation for Medical Education and Research Division of Cardiovascular Diseases. Related Content: Heart Failure With Preserved Ejection Fraction

More than 2 million individuals in the US are chronically infected with hepatitis C, and nearly 15 000 die every year. Antivirals are available but are not reaching the majority of infected individuals. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Francis S. Collins, MD, PhD, discuss a plan to eliminate hepatitis C included in the Biden-Harris 2024 budget proposal. Related Content: A National Hepatitis C Elimination Program in the United States Eliminating Hepatitis C in the United States Former NIH Director Francis S. Collins on the New White House Plan to Eliminate Hepatitis C Association of Direct-Acting Antiviral Therapy With Liver and Nonliver Complications and Long-term Mortality in Patients With Chronic Hepatitis C After 12 Years, NIH Director Francis S. Collins, MD, PhD, Seeks His Next Chapter After 12 Years, NIH Director Francis S. Collins Seeks His Next Chapter

In January 2023, the US Organ Procurement & Transplantation Network (OPTN) required transplant centers to modify transplant list wait times for Black patients. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and L. Ebony Boulware, MD, MPH, Dinushika Mohottige, MD, MPH, and Tanjala S. Purnell, PhD, MPH, discuss why the OPTN mandate is a valuable model for reforming race-based practices. Related Content: Race-Neutral Estimates of Kidney Function: Enhancing Equity Race-Based Equations Delayed Black Patients From Getting Onto Kidney Transplant Lists—An Unprecedented New Policy Seeks to Undo the Damage Redressing the Harms of Race-Based Kidney Function Estimation

Malignant primary brain tumors cause more than 15 000 deaths annually in the US. JAMA Fishbein Fellow Revital Marcus, MD, interviews Ingo Mellinghoff, MD, PhD, neuro-oncologist and chair of the department of neurology at Memorial Sloan Kettering Cancer Center in New York, about the epidemiology, diagnosis, and treatment of various primary malignant brain tumors in adults. Related Content: Glioblastoma and Other Primary Brain Malignancies in Adults

During the transition to menopause, approximately 50%-75% of individuals experience vasomotor or genitourinary symptoms. JAMA Senior Editor Linda Brubaker, MD, and Carolyn Crandall MD, MS, of the University of California, Los Angeles, discuss hormonal and nonhormonal therapy for treatment of menopausal symptoms. Related Content: Management of Menopausal Symptoms

Interview with Vanessa Northington Gamble, MD, PhD, author of Dr Herman A. Barnett, Black Civil Rights Activists, and the Desegregation of The University of Texas Medical Branch in 1949: “We Ought to Go in Texas and I Don’t Mean to a Segregated Medical School.” Hosted by Robert Steinbrook, MD, and Raegan W. Durant, MD, MPH. Related Content: Dr Herman A. Barnett, Black Civil Rights Activists, and the Desegregation of The University of Texas Medical Branch in 1949

Deverick John Anderson, MD, MPH, professor of medicine at Duke University and director of the Duke Center for Antimicrobial Stewardship and Infection Prevention, discusses the evidence and appropriate strategies used in the prevention of surgical site infections with JAMA Associate Editor Anthony Charles, MD, MPH. Related Content: Surgical Site Infection Prevention

Anxiety disorders affect approximately a third of adults during their lifetime in the US and are associated with significant distress and impairment. JAMA Deputy Editor Mary M. McDermott, MD, discusses diagnosis and treatment of anxiety disorders with Naomi M. Simon, MD, MSc, professor of the Department of Psychiatry at NYU Grossman School of Medicine. Related Article(s):

Bacterial meningitis is a worldwide health problem causing approximately 300 000 deaths annually. In this podcast, JAMA Fishbein Fellow Revital Marcus, MD, speaks with Rodrigo Hasbun, MD, MPH, infectious disease specialist and professor of medicine at the University of Texas Health Science Center in Houston, about the epidemiology, diagnosis, and treatment of bacterial meningitis. Related Content: Progress and Challenges in Bacterial Meningitis Bacterial Meningitis

Rajesh T. Gandhi, MD, director of Harvard University’s Center for AIDS Research, talks about recent advances in the treatment and prevention of HIV and discusses HIV in the context of COVID-19 and monkeypox infections. Hosted by JAMA Deputy Editor and Editorial Director for Equity Preeti Malani, MD, MSJ. Related Content: Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults Ending the HIV Epidemic Anthony Fauci, MD: Working to End HIV/AIDS

Phenome-wide association studies use large data sets to search for phenotypes associated with specific single-nucleotide variants, investigating whether specific genetic variations may be associated with multiple conditions and traits. In this podcast, JAMA Fishbein Fellow Revital Marcus, MD, discusses phenome-wide association studies with Dan M. Roden, MD, professor of medicine, pharmacology, and biomedical informatics at Vanderbilt University Medical Center, and Joshua C. Denny, MD, MS, chief executive officer of the National Institutes of Health's All of Us Research Program. Related Content: Phenome-Wide Association Studies