Questioning Medicine

The incidence of new-onset diabetes was basically the same but statistically significantly higher for those individuals on low-to-moderate–intensity statins compared with placebo 1.2 vs 1.3% annually which is a very small difference. But with  high-intensity statins compared with placebo (4.8% vs. 3.5% annually) Among patients with known diabetes at baseline, glycemia worsened slightly with statin therapy compared with placebo Here is the problem- diabetes is a number—a surrogate if you will. Statins fix a surrogate but have been proven to improve patient orientated outcomeshttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2213858724000408?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213858724000408%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.jwatch.org%2F