Blood & Cancer

Chimeric antigen receptor (CAR) T-cell therapy is one of the hottest advances in lymphoma treatment, but who should get it and what does the process look like? Allison Winter, MD, of the Cleveland Clinic helps answer those questions on the podcast. She joins Blood & Cancer host David H. Henry, MD, of the Pennsylvania Hospital, Philadelphia, to break down the side effects and look ahead to possible off-the-shelf products. In Clinical Correlation, Ilana Yurkiewicz, MD, of Stanford (Calif.) University, discusses optimism bias. She recalls a time when a patient’s drive for optimism affected what she told them and whether that was a good or bad thing.  Practice points: The time to refer a patient for CAR T-cell therapy is at relapse. CAR T-cell therapy side effects are serious and include cytokine release syndrome and neurotoxicity.*  *  *   CAR T-cell therapy use in lymphoma  For patients with diffuse large B-cell lymphoma, treatment after relapse typically involves salvage therapy, and if they are chemot