The Inquiry

Gene therapy has changed what is possible for people living with sickle cell disease.New treatments have shown that the condition can be successfully treated. But the therapy is costly and available to only a small number of patients. Millions of people around the world still rely on early diagnosis and preventative medicines, with access to basic care remaining a challenge in many places, including sub-Saharan Africa, which has almost 80% of global sickle cell cases. This week on The Inquiry, we're asking: Are we closer to gene therapy for sickle cell disease being accessible?Contributors Dr Natasha Archer, director of the Sickle Cell Program at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, US Dr Alexis Thompson, paediatric haematologist at the Children's Hospital of Philadelphia and a professor of paediatrics at the University of Pennsylvania, US Dr Leon Tshilolo, professor of paediatrics and haematology at the University of Mbuji-Mayi, DR Congo Professor Baba Inusa, consultant pae

Last year Kenya’s President William Ruto established a task force to investigate the escalating cases of gender-based violence including femicide. The task force travelled around the country gathering information and at the beginning of this year published its recommendations, which are now being debated in parliament. One of those recommendations is the legal recognition of femicide as a standalone crime. UN Women, the United Nations agency which promotes the empowerment and rights of girls and women, have been working with grassroots organisations in Kenya on male engagement strategies, to change perceptions of the role of men and women. But the UN Women’s representative in Kenya, acknowledges that challenges remain. In the meantime, women continue to march in protest and the country waits to see if President Ruto will implement the task force recommendations. So, is Kenya serious about ending femicide?Our guests this week include Shyleen Momanyi, executive director, Young Women’s Leadership Institute, Nair

Flesh-eating parasitic flies have been found in the US state of Texas for the first time in decades. Known as the New World Screwworm, officials have now put plans in place to try and contain its spread. The fly feeds off warm-blooded animals, like cattle, dogs and horses, but if detected early enough, with treatment, the animals can make a full recovery. It can also infest humans, but human deaths are rare and it poses no food safety issues. The New World Screwworm is not a new problem; it is considered endemic in South America and some parts of Central America, towards South America. But despite the United States declaring itself screwworm free in the 1960s, the country has since seen several outbreaks. Officials have been tracking this latest case since late 2024. To date, the most widely used method to try and control the spread of the screwworm is the Sterile Insect Technique, whereby millions of flies are hatched and exposed to radiation, before they are released into the wild. And the idea here is th

This year, technology has more influence in officiating sports than ever before.At the men's World Cup, the role of virtual assistant referee technology (VAR) has been extended to include two more on-pitch scenarios while in tennis, umpires use electric line calling systems (ELC) to make final decisions.Both bits of kit aim to improve the accuracy. It’s become easier to consider match-defining moments through these tracking and review systems’ specialised cameras. But, this information takes human officials valuable time to analyse.Football fans criticise VAR for this reason, saying it delays match momentum. Top ranking tennis players Aryna Sabalenka and Alexander Zverev have also complained as these systems are not yet infallible. If technology is as imperfect as a human referee or umpire and can interrupt the fan experience too, why do elite sports rely on it?This week on The Inquiry we’re asking, ‘Is technology ruining sport?’Contributors Carlo de Marchis, independent advisor in sports and media technology

A new directive strives to narrow the 11% hourly wage gap between men and women in the EU.Around the world, the gender pay gap has been shrinking as women gain access to higher education and better employment opportunities. Though varied hours, industries and care responsibilities make this inequality a difficult problem to tackle with one universal policy.Member states have just passed their deadline to implement measures that will hold employers to account for pay disparities in the workplace so will pay transparency solve the persistent gap?Contributors: Emma Duchini, assistant professor of economics, University of Essex, UK Marianne Bertrand, professor of economics, University of Chicago Booth School of Business, US Adamnesh Bogale, head of gender, African Centre for Economic Transformation (ACET), Ghana Marina Tverdostup, economist, Vienna Institute for International Economic Studies, AustriaPresenter: Charmaine Cozier Producer: Evie Yabsley Researcher: Amelia Cox Editor: Tom Bigwood Technical Producer:

In May 2026, the World Health Organization declared an Ebola outbreak in western Africa a public health emergency of international concern. Within days, hundreds of cases had been recorded in the Democratic Republic of Congo, raising fears that the virus could spread further across the region.Ebola has been causing outbreaks for nearly 50 years, but despite advances in vaccines and treatments, the disease continues to return. But why is it so difficult to treat and contain? This week on The Inquiry, we’re asking: “Why does Ebola keep coming back?”Contributors: Syra Madad, infectious disease epidemiologist at the Harvard Belfer Centre, US Hypolite Muhindo Mavoko, professor of tropical medicine at the University of Kinshasa, the Democratic Republic of Congo Amanda Rojek associate professor of health emergencies at the University of Oxford, UK Julienne Anoko, risk communication and community engagement officer at the World Health Organization Regional Office for Africa, KenyaPresenter: Tanya Beckett Producer: M

In 2001, Portugal decriminalised the possession and use of all illicit drugs. It was a move designed to mitigate the country’s public health crisis, which at the time meant Portugal had one of the worst rates of overdose deaths in Europe, as well as the highest rate of HIV among drug users. Whilst drugs remained illegal, users did not receive a criminal record but were instead referred to rehabilitation and treatment programmes. It was an approach that proved so successful, that it has remained in place for a quarter of a century. But just over 10 years after its introduction, Portugal’s drugs policy started to come under strain as the country’s economic crisis and subsequent austerity measures led to budget cuts for drug services. More recently the rising cost of living has diverted people’s attention from investment in this field. On top of this, the trafficking of cocaine and newer substances into the country along with changing demographics is putting decriminalisation under strain. So, on The Inquiry thi

At the beginning of this year Bulgaria, considered as one of the poorest countries in the European Union, became the latest to officially join the eurozone. Bulgaria’s legal tender since 1881 had been the lev, but since the mid-1990s it had been pegged to other European currencies, first to the German deutschmark and now to the euro. But it remains to be seen if the country’s economic policy can take advantage of the opportunities that joining the single currency can afford, in terms of trade and economic development. Monetary unions are not a new concept, some like the Scandinavian monetary union date back to the 19th Century, involving Denmark, Sweden and Norway. It established a fixed exchange rate system based on the gold standard, whilst member countries still had their own currencies before it was gradually dissolved from the outbreak of World War One onwards. Today, the biggest monetary union is the eurozone, used by around 358 million people across 21 European Union countries. It has one monetary aut

The Himalayan glaciers are melting more rapidly as global temperatures rise, raising concerns about the future of ecosystems and communities across the Himalayan mountain range. Glaciers store more than two thirds of the world’s freshwater and help regulate global temperatures by reflecting the sun’s rays.Across South Asia, melting ice is contributing to the formation of unstable glacial lakes and increasing the risks of floods, droughts and avalanches. The Himalayas are a vital source of water for millions of people, supporting agriculture, energy production and livelihoods from tourism.Experts warn that continued glacier loss could have significant consequences for people living in the region and the mountainous ecosystem, but what can be done to respond to these changes?Contributors: Pasang Yangjee Sherpa, assistant professor at the University of British Columbia, Canada Pam Pearson, director and founder of the International Cryosphere Climate Initiative, US Matthias Huss, glaciologist and senior scientis

The recent election result in Hungary has been seen as a welcome relief within the European Union.The bloc of 27 nations has, at times, felt frustrated with the country for blocking what the other 26 members have agreed to do, especially regarding financial support for Ukraine.Now the EU has been able to push through a loan to Ukraine of more than US$100bn, and some observers believe the union’s turbulent years are behind it. As it marks 10 years since the United Kingdom voted to leave, and with Montenegro expected to soon join, this week, what is the future of the European Union?’Contributors: Dr Monika Sus, professor at the Polish Academy of Sciences and at the Robert Schuman Centre of the European University Institute in Florence, Italy Michael Geary, professor of European history at the Norwegian University of Science and Technology, Norway Catherine E. de Vries, author How Europe Survives: The Adaptability and Resilience of a Continent in Peril, vice dean of the school for politics, economics and global

Global oil markets have been affected by the US Israel war with Iran, leading to higher jet fuel prices and increased attention on supply risks.But how serious is the situation? While some experts point to tightening supply chains and regional bottlenecks, others say there is no clear evidence so far of immediate shortages.Even so, the refining and distribution of jet fuel remains a potential vulnerability, as disruption can have notable impacts even when crude oil itself is available. With air travel crucial to trade and tourism, the resilience of fuel supply is a growing concern for economies and travellers. Can alternative suppliers and fuel sources help limit the impact of future disruption?This week on The Inquiry, we’re asking: are countries really running out of jet fuel?Contributors Zach Aman, professor of chemical engineering, the University of Western Australia Ahmed Mehdi, senior fellow at the Oxford Institute for Energy Studies and managing director at Renaissance Energy Advisors, UK Dumebi Oluw

The recent Nasa Artemis II crewed mission to the far side of the Moon is a further step towards a long-term return to the lunar surface and future missions to Mars. The plan is that before the end of the decade there will be a crewed landing and the start of a Moon base. China is among those developing similar plans. Previous missions both crewed and uncrewed have provided evidence of resources that potentially could be of use here on Earth, and support human life on the Moon. So, it’s not just the race to the Moon that’s capturing the world’s attention, but also the possible economic benefits that that might bring with it. The Moon’s surface or lunar regolith contains volatiles like hydrogen, carbon dioxide and methane. There is evidence of minerals such as silicate and oxides and metals like aluminium and titanium, which could be extracted for building materials. And something that is rare on Earth, Helium-3, a potential resource for clean fusion energy. Governments in conjunction with private corporatio

Conflict in the Middle East has led to volatility in global oil prices, pushing up fuel costs worldwide. Previous oil shocks prompted some countries to reconsider their reliance on cars, investing in alternatives such as cycling. In some places, this has become part of everyday life, while elsewhere it has proved more contested, reflecting wider political and cultural divides.Cycling offers benefits for health and the environment, but it is not practical for everyone. For many people, including those in rural areas or with limited mobility, cars remain everyday essentials. As oil price volatility continues to affect motorists, questions remain about how far behaviour can change.This week on The Inquiry, we’re asking: is it time to swap four wheels for two?Contributors: Meredith Glaser, CEO of Urban Cycling Institution, professor of cycling at Ghent University, Belgium, and a senior lecturer at the University of Amsterdam, the Netherlands Levke Sönksen, research associate at the German Institute of Urban Affai

Broadcasters from The Netherlands, Ireland, Iceland, Spain and Slovenia are all boycotting May’s Eurovision Song Contest because Israel is participating. Sources within Israel’s broadcaster say calls for it to be banned are unjustified, and organisers of the contest insist it must remain politically neutral, describing the event as "a platform for displaying the importance of peace and unity in a divided world".The boycott has sparked one of the biggest crises in Eurovision’s 70-year history. In several cases, the position to withdraw also reflects wider pressure from politicians and public opinion. How will countries boycotting Eurovision affect the contest?’Contributors: Natalija Gorščak, president of the management board of RTV, Slovenia Dr Bárbara Barreiro León, lecturer in film and visual Culture, University of Aberdeen, UK Dr Heather Dichter, associate professor of sport history and sport management, De Montfort University, UK Dr Dean Vuletic, author Postwar Europe and the Eurovision Song Contest, Luxem

For the second time in 12 years Glasgow is preparing to host the Commonwealth Games after Australia’s Victoria state pulled out because of increased costs. Victoria’s withdrawal raised questions about whether the 2026 games would go ahead before Glasgow agreed to step in. Staging a sporting mega-event is expensive and governments face increasing scrutiny over public spending. Victoria’s decision raised wider questions about affordability for potential hosts. At the same time, critics question the Games’ political relevance, given its origins in Britain’s colonial past.The Commonwealth Games Federation says the event can be delivered in a more sustainable way and argues that it brings cultural and economic benefits to host cities, but recent editions have run into significant costs and budget pressures.This week on The Inquiry, Tanya Beckett asks ‘Is it time to scrap the Commonwealth Games?’Contributors: Dr Stuart Whigham, senior lecturer in sport, coaching and physical education at Oxford Brookes University,

Ireland has a new permanent government scheme providing regular cash transfers to 2,000 artists. The people who can access it range from circus performers to opera singers.It follows a pilot of more than three years, which is believed to have brought a return on investment to the economy.Big tech backs basic income schemes like this to offset the consequences AI is having on the workforce. Leading economists believe it could create a dystopian world. Nevertheless, more governments are piloting or planning to introduce schemes like this.Our panel includes Dr Jenny Dagg, assistant lecturer, Maynooth University, Ireland; Dr Catarina Neves, postdoctoral fellow, Utrecht University, The Netherlands; Daron Acemoglu, 2024 Nobel Prize winner in economics, institute professor, Massachusetts Institute of Technology, US and Dr Jurgen De Wispelaere, acting chair of the Basic Income Earth Network.Presenter: Charmaine Cozier Producer: Daniel Rosney Sound engineer: Craig Boardman Editor: Tom Bigwood(Photo: A customer withdra

Cuba is facing one of its most severe humanitarian crises in decades.For years, Cuba relied heavily on oil from Venezuela. Those supplies have largely stopped, contributing to widespread fuel shortages. Electricity blackouts have become increasingly common, disrupting daily life across the country.The United States has blocked fuel shipments to Cuba as part of wider pressure linked to its economic and political policies. Meanwhile, the Cuban government has warned it will resist any external interference in its domestic affairs.With economic strain growing and living conditions worsening, this week on The Inquiry, we’re asking: ‘Is the revolution in Cuba over?’Contributors: Lillian Guerra, professor of Cuban and Caribbean history at the University of Florida, US Ricardo Torres, research fellow at American University, US Christopher Sabatini, senior research fellow for Latin America at Chatham House, UK Renata Segura, programme director for Latin America and the Caribbean at the International Crisis Group, USPr

Rewilding, or letting nature take care of itself, can restore stability to damaged ecosystem components which support life on earth, like fungi, bacteria, vegetation, insects and animals.But there's now a wider discussion to discover what it’s capable of on a wider scale.International agreements for reducing the impact of climate change tend to set global targets.However, individual governments decide how to work towards meeting those goals at a national level.Some rewilding initiatives improve biodiversity, but it can have negative impacts too.This week on The Inquiry, we’re asking ‘How can rewilding help combat climate change?’Contributors: Carolina Soto-Navarro, head of Wilder Nature at Rewilding Europe Brendan Fisher, professor in the Rubenstein School of Environment and Natural Resources, at University of Vermont, US David Nogues Bravo, professor in biodiversity, University of Copenhagen, Denmark Steve Carver, professor of rewilding and wilderness science, University of Leeds, UKPresenter: Charmaine Co

In February, Polish Prime Minister Donald Tusk posted a social media video celebrating new figures from the International Monetary Fund suggesting that the average person in Poland now has slightly more spending power than the average person in Spain, the European Union’s fourth largest economy. It’s a symbolic milestone for a country that emerged from communism just over three decades ago and once struggled with hyperinflation and economic upheaval. In 2025, Poland’s economy also passed the trillion-dollar mark, putting it in an elite group of just 20 countries globally.Investment from across the EU has helped drive growth. But can Poland keep its edge as labour shortages grow and the war in neighbouring Ukraine continues to shape the region? This week on The Inquiry, Tanya Beckett asks: Why is Poland’s economy booming?Contributors: Dr Pawel Bukowski, lecturer in economics at University College London and Polish Academy of Sciences, UK Iga Magda, associate professor at the Warsaw School of Economics, Poland

Half a million people are in Spain without official permission. They come mainly from Colombia, Peru, Honduras, Paraguay, and Argentina. It’s thought that most outstay their work, student, or tourist visas. An amnesty to grant them legal status to remain and work is due to start within weeks.It's a very different approach from most other countries in Europe that have been tightening controls on migration.The prime minister has admitted “Some say we've gone too far, that we're going against the current”.Opposition parties argue that this policy puts pressure on public services.This week on The Inquiry, we’re asking: “How will Spain’s migrant amnesty work?”Contributors: Ismael Gálvez Iniesta, assistant professor, department of applied economics, Universitat de les Illes Balears, Spain Donna Cabrera, independent researcher, international migration lecturer, Pontificia Universidad Javeriana, Colombia Alana Moceri, international relations professor, IE University, Spain Joan Monràs, economics professor, Universita