Carta - Center For Academic Research And Training In Anthropogeny (audio)

Africa is thought to be the ancestral homeland of all modern human populations within the past 300,000 years. It is also a region of tremendous cultural, linguistic, climatic, and genetic diversity. Despite the important role that African populations have played in human history, they remain one of the most underrepresented groups in human genomics studies. A comprehensive knowledge of patterns of variation in African genomes is critical for a deeper understanding of human genomic diversity, the identification of functionally important genetic variation, the genetic basis of adaptation to diverse environments and diets, and the origins of modern humans. We have characterized genomic variation in thousands of ethnically and geographically diverse Africans in order to reconstruct human population history and local adaptation to variable environments and have identified candidate loci that play a role in alcohol metabolism and skin color. Series: "CARTA - Center for Academic Research and Training in Anthropogeny

The first Neandertal DNA was recovered 25 years ago, and since then, ancient DNA has provided many surprising insights into human evolutionary history. Among these are the discoveries of the multiple admixture events among late Pleistocene humans and the remnants of archaic DNA in our own genomes. How does ancient DNA research contribute to the future of anthropogeny? In this talk, I will reflect on the findings of last quarter century of ancient DNA research about archaic humans and their environment as well as examine potential questions that the next quarter century might answer. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38303]

Our species is between 300,000 and 200,000 years old. For most of this one-quarter of a million years, up until just 12,000 years ago, it appears that our ancestors lived in small populations, in small-scale societies of which we can only guess the real nature. We remain in the dark about the age of some of the most diagnostic features of our species: our striding bipedalism, complex tool manufacture and use, fire use, language and societies defining their own identities, collaborating with and competing against neighboring societies. Data from studies of non-human animal behavior remind us of the underappreciated capacities of many other species. However, it has so far not provided evidence for any other species that shares the long list of distinctly human characteristics; chief among those, our species’ capacity to not only simultaneous modify and threaten planetary ecosystems but also document and study such ecosystems across the globe. Series: "CARTA - Center for Academic Research and Training in Anthrop

The discovery and resolution of genetic variation is critical to understanding disease and evolution. Our most recent work sequences diverse human and nonhuman primate genomes using both ultra-long and high-fidelity long-read sequencing technologies. Advances in this area have made possible the first telomere-to-telomere assemblies of the human genome and much more complete chimp, gorilla and orangutan genomes providing new biological insights into regions typically excluded from human genetic and comparative studies. We have discovered mega basepairs of duplicated sequence and/or rapidly evolving sequence present in humans that are absent from other non-human primates. These changes have predisposed our species to recurrent rearrangements associated with disease but also have led to the emergence of new genes important in the expansion of the human frontal cortex of the brain. Our data suggest that large-scale genome structural variation has played and continues to play a crucial role in the evolution of the

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show I

The human brain has a larger mass with respect to body weight, increased cortical neurons with respect to size, an expanded proliferative zone, and unique connectivity patterns. Human-specific neurodevelopment is not only marked by physical differences, but also by temporal changes. Human neurons, during both prenatal neurodevelopment and adult neurogenesis, exhibit an exceptionally delayed time course, a characteristic termed neoteny. Signatures of human-specific neoteny have been observed and reproduced across different systems including induced pluripotent stem cell (iPSC) and brain organoids models. We compared neurogenesis across stem cells from five primate species - rhesus, gorilla, bonobo, chimpanzee, human - and assessed the differences in transcriptional dynamics. We identified a pioneer transcription factor, GATA3, that exhibited elevated neuronal expression only in humans. This finding provides evidence for the divergence of gene regulation as a contributor to human neoteny. Series: "CARTA - Cente

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. David Holway addresses the challenges of emerging invasive species in our ecosystem. Oliver Ryder discusses the accelerated rate of loss of species due to human activities. Patricia Hunt talks about how human made chemicals and pollutants are impacting global fertility rates. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38207]

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. Rob Knight will talk about how all microbiomes that have been studies are impacted by human activity. Alice Goramn discusses how accumulating space debris surrounding our planet that may prevent us from leaving the Earth in the future. Asher Rosinger addresses the global water challenges that humans may face as climate change begins to affect water supplies. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38206]

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. Walter Willett will discuss how climate change is having devastating effects that will undermine our ability to feed the world’s growing population. Jessica Thompson talks about humans transformed the environment and the damage it has done to our ecosystem. Finally, David Tilman addresses the global alteration of Earth's nitrogen cycle, and what it means for u as a species moving forward. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38205]

This CARTA public symposia addresses specific examples of how humans have drastically altered the planet. Acknowledged experts discuss clearly defined global-scale negative impacts on planet earth, our life support system (other than climate change, population growth and infectious diseases, which are well-known). Each talk succinctly describes a specific impact, the role that our species has played, and concludes with ongoing or potential approaches to mitigation. In the process, we come full circle to Anthropogeny, asking how a single species could have evolved the ability to so drastically alter the entire planet. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38009]

Through the Earth Microbiome Program and complementary efforts, we have sampled a broad range of microbiomes from across the planet. All microbiomes that have been studied are impacted by human activity — the effects of industrialization on the human microbiome are best characterized, but capture of animals in zoos, domestication, modification of soils through agricultural practices, and modification of freshwater and marine microbiomes have also all been well characterized. Indeed, the pervasive role of environmental microbiomes in biogeochemical cycles necessary to sustain life led to a position paper entitled "Scientists’ warning to humanity: microorganisms and climate change”, the title of which speaks for itself. However, there is hope. Efforts such as the Microbiota Vault will be especially important in this respect, but also new monitoring and modeling approaches will help us understand where to look globally for the best specimens and microbes to preserve. Series: "CARTA - Center for Academic Research

In 1957, the USSR launched Sputnik 1, the first human object to leave Earth. In the 65 years since then the region of Earth orbit has become filled with satellites and space junk. The proliferation of debris has led to the prediction of Kessler Syndrome, a state where a never-ending cascade of collisions between orbital objects renders parts of space unusable for human purposes. However, there are many different ways to look at the space junk surrounding Earth. For example, it is also an archaeological record of humanity’s first steps into outer space, a cultural landscape created by the combined effects of natural and cultural processes, and a technological signature of the same kind that SETI (Search for Extraterrestrial Intelligence) researchers are looking for around exoplanets in other solar systems. It’s unclear when or whether the tipping point into Kessler Syndrome might be reached, but if humanity is confined to Earth in the future, what will this mean? Series: "CARTA - Center for Academic Research a

We are experiencing an accelerated rate of loss of species due to human activities. This anthropogenic phenomenon extends beyond extinction. It encompasses an expanded loss of biodiversity as the genetic diversity of species diminish, reducing gene pools to “gene puddles.” We know details of species extinctions events from the fossil record, historical record, and from ancient DNA studies, and that historical processes shape extinction risk. Habitat loss and changing eco-environmental conditions, competition, and other factors produce genomic impacts, also influencing extinction risk. The legacy of past events impacts resiliency of species in the current environment in interpretable ways. Demographic trajectories reveal vulnerability to extinction. Remarkable advances in genomics technologies portend a deeper understanding of the evolution of life and the vulnerability of extant species to changes now taking place through human agency. Series: "CARTA - Center for Academic Research and Training in Anthropogeny

Humans now annually add more biologically available nitrogen to the Earth’s land surfaces than do all natural processes. For 3 billion years, available nitrogen had been the major limiting currency for life on Earth. The recent human disruption of the global nitrogen cycle is causing major environmental harm, including water and air pollution, marine dead zones, 10% of global greenhouse gas emissions, and species extinctions. Three major ways to solve this nitrogen problem are: (1) much more efficient global use of nitrogen fertilizers; (2) shifts to lower-meat and healthier diets; and (3) halting the conversion of food crops into biofuels, such as US corn ethanol used for transport. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37910]

We are losing species much more rapidly now than in the last two million years! At this pace, we may lose a large proportion of vertebrates, including mammals, birds, reptiles, amphibians, and fishes, in the next two to three decades. Modern extinctions caused by human activities are higher than the normal or natural extinction rate which tells us that we may be causing a mass extinction. In the history of life on Earth, there have been five mass extinctions – episodes where large numbers of species became extinct in a short period of time. All mass extinctions have been caused by natural catastrophes, such as the impact of a meteorite. We are the only species that has the capability to save all endangered animals. Paradoxically, saving them is the only way to save humanity. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37904]

This CARTA public symposia addresses specific examples of how humans have drastically altered the planet. Acknowledged experts will discuss clearly defined global-scale negative impacts on planet earth, our life support system (other than climate change, population growth and infectious diseases, which are well-known). Each talk succinctly describes a specific impact, the role that our species has played, and concludes with ongoing or potential approaches to mitigation. In the process, we are coming full circle to Anthropogeny, asking how a single species could evolve the ability to so drastically alter the entire planet. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38008]

Beginning with Homo erectus at least a million years ago, hominins have used fire to engineer the world around them. The earliest uses of fire surely included cooking, changing the energy yields of foods. Such innovations altered the course of our evolution, facilitating the evolution of species that could adapt quickly using tools and social ingenuity. Within the last 200,000 years, hominins also used fire to change the material properties of stone, pigments, sap, and wood. While these changes represent a fundamental shift in the role of humans as dominant shapers of their environments through years of evolution and innovation, ecosystems adjusted as early humans remained embedded within them. However, humans are not now simply shifting to another sustainable balance - we are pushing environmental thresholds across one tipping point after the next. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37907]

The introduction of species into new environments has occurred throughout human history. While most introductions fail and most of those few that establish remain environmentally innocuous, a notable minority wildly proliferates in their new ranges. These invaders disrupt ecosystems and burden economies. Environmental impacts associated with invasions are hard to predict and vary in space and time but include ecosystem-level disruptions, species extinctions, and the homogenization of biodiversity. Economic costs, while challenging to quantify, are enormous and growing. Given that established invaders are difficult to eradicate, let alone manage, stopping invasions before they start remains the most effective strategy to limit further costs resulting from invasions. Challenges to implementing this approach include regulating trade and coordinating rapid governmental responses to emerging threats. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37905]

Humans have adapted to meet their water needs across disparate environments over time using behavioral adaptations. Yet, as temperatures rise and freshwater sources become depleted, it is critical to understand 1) how populations modify their environments to meet their water needs, and 2) the consequences of these anthropogenic - or human caused changes - on the environment and further on human health. This talk will provide an overview of different global water challenges and focus on a couple of case studies to highlight how development projects in remote areas that provide easier access to water, which may be high in salt or other contaminants, can unintentionally worsen health outcomes and hasten water depletion. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37908]

Human-made chemicals with the unexpected ability to interfere with our body’s endocrine system have become prominent contaminants in daily life. Because the hormones produced by our endocrine system create complex signaling networks that control our growth, maturation, fertility, immunity, behavior, and sleep, these endocrine disrupting chemicals, or EDCs, can exert powerful biological effects. Declines in human fertility evidenced by falling sperm counts and increases in the incidence of infertility raise concern that daily exposure to EDC contaminants already is impacting human fertility. By design, all species are responsive to their environment. In humans, this responsiveness means that changes in our environment can affect the production of eggs and sperm, the growth and development of the fetus, and adult susceptibility to disease. Thus, in a 21st century world characterized by environmental crises, EDCs represent a planetary health problem with the potential to affect future generations. Series: "CARTA