80,000 Hours Podcast With Rob Wiblin

Will the future of humanity be wild, or boring? It's natural to think that if we're trying to be sober and measured, and predict what will really happen rather than spin an exciting story, it's more likely than not to be sort of... dull. But there's also good reason to think that that is simply impossible. The idea that there's a boring future that's internally coherent is an illusion that comes from not inspecting those scenarios too closely. At least that is what Holden Karnofsky — founder of charity evaluator GiveWell and foundation Open Philanthropy — argues in his new article series titled 'The Most Important Century'. He hopes to lay out part of the worldview that's driving the strategy and grantmaking of Open Philanthropy's longtermist team, and encourage more people to join his efforts to positively shape humanity's future. Links to learn more, summary and full transcript. The bind is this. For the first 99% of human history the global economy (initially mostly food production) grew very slowl

Chris Olah has had a fascinating and unconventional career path. Most people who want to pursue a research career feel they need a degree to get taken seriously. But Chris not only doesn't have a PhD, but doesn’t even have an undergraduate degree. After dropping out of university to help defend an acquaintance who was facing bogus criminal charges, Chris started independently working on machine learning research, and eventually got an internship at Google Brain, a leading AI research group. In this interview — a follow-up to our episode on his technical work — we discuss what, if anything, can be learned from his unusual career path. Should more people pass on university and just throw themselves at solving a problem they care about? Or would it be foolhardy for others to try to copy a unique case like Chris’? Links to learn more, summary and full transcript. We also cover some of Chris' personal passions over the years, including his attempts to reduce what he calls 'research debt' by starting a n

Big machine learning models can identify plant species better than any human, write passable essays, beat you at a game of Starcraft 2, figure out how a photo of Tobey Maguire and the word 'spider' are related, solve the 60-year-old 'protein folding problem', diagnose some diseases, play romantic matchmaker, write solid computer code, and offer questionable legal advice. Humanity made these amazing and ever-improving tools. So how do our creations work? In short: we don't know. Today's guest, Chris Olah, finds this both absurd and unacceptable. Over the last ten years he has been a leader in the effort to unravel what's really going on inside these black boxes. As part of that effort he helped create the famous DeepDream visualisations at Google Brain, reverse engineered the CLIP image classifier at OpenAI, and is now continuing his work at Anthropic, a new $100 million research company that tries to "co-develop the latest safety techniques alongside scaling of large ML models". Links to learn more, sum

If you wanted to start a university department from scratch, and attract as many superstar researchers as possible, what’s the most attractive perk you could offer? How about just not needing an email address. According to today's guest, Cal Newport — computer science professor and best-selling author of A World Without Email — it should seem obscene and absurd for a world-renowned vaccine researcher with decades of experience to spend a third of their time fielding requests from HR, building management, finance, and so on. Yet with offices organised the way they are today, nothing could be more natural. Links to learn more, summary and full transcript. But this isn’t just a problem at the elite level — this affects almost all of us. A typical U.S. office worker checks their email 80 times a day, once every six minutes on average. Data analysis by RescueTime found that a third of users checked email or Slack every three minutes or more, averaged over a full work day. Each time that happens our focus

The effective altruist research community tries to identify the highest impact things people can do to improve the world. Unsurprisingly, given the difficulty of such a massive and open-ended project, very different schools of thought have arisen about how to do the most good. Today's guest, Alexander Berger, leads Open Philanthropy's 'Global Health and Wellbeing' programme, where he oversees around $175 million in grants each year, and ultimately aspires to disburse billions in the most impactful ways he and his team can identify. This programme is the flagship effort representing one major effective altruist approach: try to improve the health and wellbeing of humans and animals that are alive today, in clearly identifiable ways, applying an especially analytical and empirical mindset. Links to learn more, summary, Open Phil jobs, and full transcript. The programme makes grants to tackle easily-prevented illnesses among the world's poorest people, offer cash to people living in extreme poverty, prevent

When the first person with COVID-19 went to see a doctor in Wuhan, nobody could tell that it wasn’t a familiar disease like the flu — that we were dealing with something new. How much death and destruction could we have avoided if we'd had a hero who could? That's what the last Assistant Secretary of Defense Andy Weber asked on the show back in March. Today’s guest Pardis Sabeti is a professor at Harvard, fought Ebola on the ground in Africa during the 2014 outbreak, runs her own lab, co-founded a company that produces next-level testing, and is even the lead singer of a rock band. If anyone is going to be that hero in the next pandemic — it just might be her. Links to learn more, summary and full transcript. She is a co-author of the SENTINEL proposal, a practical system for detecting new diseases quickly, using an escalating series of three novel diagnostic techniques. The first method, called SHERLOCK, uses CRISPR gene editing to detect familiar viruses in a simple, inexpensive filter paper test,

History is filled with stories of great people stepping up in times of crisis. Presidents averting wars; soldiers leading troops away from certain death; data scientists sleeping on the office floor to launch a new webpage a few days sooner. That last one is barely a joke — by our lights, people like today’s guest Max Roser should be viewed with similar admiration by historians of COVID-19. Links to learn more, summary and full transcript. Max runs Our World in Data, a small education nonprofit which began the pandemic with just six staff. But since last February his team has supplied essential COVID statistics to over 130 million users — among them BBC, The Financial Times, The New York Times, the OECD, the World Bank, the IMF, Donald Trump, Tedros Adhanom, and Dr. Anthony Fauci, just to name a few. An economist at Oxford University, Max Roser founded Our World in Data as a small side project in 2011 and has led it since, including through the wild ride of 2020. In today's interview Max explains how h

It can be tough to get people to truly care about reducing existential risks today. But spare a thought for the longtermist of the 17th century: they were surrounded by people who thought extinction was literally impossible. Today’s guest Tom Moynihan, intellectual historian and author of the book X-Risk: How Humanity Discovered Its Own Extinction, says that until the 18th century, almost everyone — including early atheists — couldn’t imagine that humanity or life could simply disappear because of an act of nature. Links to learn more, summary and full transcript. This is largely because of the prevalence of the ‘principle of plenitude’, which Tom defines as saying: “Whatever can happen will happen. In its stronger form it says whatever can happen will happen reliably and recurrently. And in its strongest form it says that all that can happen is happening right now. And that's the way things will be forever.” This has the implication that if humanity ever disappeared for some reason, then it would h

In 2003, Saddam Hussein refused to let Iraqi weapons scientists leave the country to be interrogated. Given the overwhelming domestic support for an invasion at the time, most key figures in the U.S. took that as confirmation that he had something to hide — probably an active WMD program. But what about alternative explanations? Maybe those scientists knew about past crimes. Or maybe they’d defect. Or maybe giving in to that kind of demand would have humiliated Hussein in the eyes of enemies like Iran and Saudi Arabia. According to today’s guest Robert Wright, host of the popular podcast The Wright Show, these are the kinds of things that might have come up if people were willing to look at things from Saddam Hussein’s perspective. Links to learn more, summary and full transcript. He calls this ‘cognitive empathy’. It's not feeling-your-pain-type empathy — it's just trying to understand how another person thinks. He says if you pitched this kind of thing back in 2003 you’d be shouted down as a 'Sad

Today's episode is one of the most remarkable and really, unique, pieces of content we’ve ever produced (and I can say that because I had almost nothing to do with making it!). The producer of this show, Keiran Harris, interviewed our mutual colleague Howie about the major ways that mental illness has affected his life and career. While depression, anxiety, ADHD and other problems are extremely common, it's rare for people to offer detailed insight into their thoughts and struggles — and even rarer for someone as perceptive as Howie to do so. Links to learn more, summary and full transcript. The first half of this conversation is a searingly honest account of Howie’s story, including losing a job he loved due to a depressed episode, what it was like to be basically out of commission for over a year, how he got back on his feet, and the things he still finds difficult today. The second half covers Howie’s advice. Conventional wisdom on mental health can be really focused on cultivating willpower — telli

For a chance to prevent enormous amounts of suffering, would you be brave enough to drive five hours to a remote location to meet a man who seems likely to be your enemy, knowing that it might be an ambush? Today’s guest — Leah Garcés — was. That man was a chicken farmer named Craig Watts, and that ambush never happened. Instead, Leah and Craig forged a friendship and a partnership focused on reducing suffering on factory farms. Leah, now president of Mercy For Animals (MFA), tried for years to get access to a chicken farm to document the horrors she knew were happening behind closed doors. It made sense that no one would let her in — why would the evil chicken farmers behind these atrocities ever be willing to help her take them down? But after sitting with Craig on his living room floor for hours and listening to his story, she discovered that he wasn’t evil at all — in fact he was just stuck in a cycle he couldn’t escape, forced to use methods he didn’t endorse. Links to learn more, summary and

Imagine that you’re in the hospital for surgery. This kind of procedure is always safe, and always successful — but it can take anywhere from one to ten hours. You can’t be knocked out for the operation, but because it’s so painful — you’ll be given a drug that makes you forget the experience. You wake up, not remembering going to sleep. You ask the nurse if you’ve had the operation yet. They look at the foot of your bed, and see two different charts for two patients. They say “Well, you’re one of these two — but I’m not sure which one. One of them had an operation yesterday that lasted ten hours. The other is set to have a one-hour operation later today.” So it’s either true that you already suffered for ten hours, or true that you’re about to suffer for one hour. Which patient would you rather be? Most people would be relieved to find out they’d already had the operation. Normally we prefer less pain rather than more pain, but in this case, we prefer ten times more pain — just because the pain woul

Donald Trump’s attempt to overturn the results of the 2020 election split the Republican party. There were those who went along with it — 147 members of Congress raised objections to the official certification of electoral votes — but there were others who refused. These included Brad Raffensperger and Brian Kemp in Georgia, and Vice President Mike Pence. Although one could say that the latter Republicans showed great courage, the key to the split may lie less in differences of moral character or commitment to democracy, and more in what was being asked of them. Trump wanted the first group to break norms, but he wanted the second group to break the law. And while norms were indeed shattered, laws were upheld. Today’s guest Mike Berkowitz, executive director of the Democracy Funders Network, points out a problem we came to realize throughout the Trump presidency: So many of the things that we thought were laws were actually just customs. Links to learn more, summary and full transcript. So once you

Today we're launching a new podcast feed that might be useful to you and people you know. It's called 'Effective Altruism: An Introduction', and it's a carefully chosen selection of ten episodes of this show, with various new intros and outros to guide folks through them. Basically, as the number of episodes of this show has grown, it has become less and less practical to ask new subscribers to go back and listen through most of our archives. So naturally new subscribers want to know... what should I listen to first? What episodes will help me make sense of effective altruist thinking and get the most out of new episodes? We hope that 'Effective Altruism: An Introduction' will fill in that gap. Across the ten episodes, we cover what effective altruism at its core really is, what folks who are tackling a number of well-known problem areas are up to and why, some more unusual and speculative problems, and how we and the rest of the team here try to think through difficult questions as clearly as poss

You might have heard fears like this in the last few years: What if Donald Trump was woken up in the middle of the night and shown a fake video — indistinguishable from a real one — in which Kim Jong Un announced an imminent nuclear strike on the U.S.? Today’s guest Nina Schick, author of Deepfakes: The Coming Infocalypse, thinks these concerns were the result of hysterical reporting, and that the barriers to entry in terms of making a very sophisticated ‘deepfake’ video today are a lot higher than people think. But she also says that by the end of the decade, YouTubers will be able to produce the kind of content that's currently only accessible to Hollywood studios. So is it just a matter of time until we’ll be right to be terrified of this stuff? Links to learn more, summary and full transcript. Nina thinks the problem of misinformation and disinformation might be roughly as important as climate change, because as she says: “Everything exists within this information ecosystem, it encompasses everyth

How long do you think it’ll be before we’re able to bend the weather to our will? A massive rainmaking program in China, efforts to seed new oases in the Arabian peninsula, or chemically induce snow for skiers in Colorado. 100 years? 50 years? 20? Those who know how to write a teaser hook for a podcast episode will have correctly guessed that all these things are already happening today. And the techniques being used could be turned to managing climate change as well. Today’s guest, Kelly Wanser, founded SilverLining — a nonprofit organization that advocates research into climate interventions, such as seeding or brightening clouds, to ensure that we maintain a safe climate. Links to learn more, summary and full transcript. Kelly says that current climate projections, even if we do everything right from here on out, imply that two degrees of global warming are now unavoidable. And the same scientists who made those projections fear the flow-through effect that warming could have. Since our best ca

How many words in U.S. newspapers have been spilled on tax policy in the past five years? And how many words on CRISPR? Or meat alternatives? Or how AI may soon automate the majority of jobs? When people look back on this era, is the interesting thing going to have been fights over whether or not the top marginal tax rate was 39.5% or 35.4%, or is it going to be that human beings started to take control of human evolution; that we stood on the brink of eliminating immeasurable levels of suffering on factory farms; and that for the first time the average American might become financially comfortable and unemployed simultaneously? Today’s guest is Ezra Klein, one of the most prominent journalists in the world. Ezra thinks that pressing issues are neglected largely because there's little pre-existing infrastructure to push them. Links to learn more, summary and full transcript. He points out that for a long time taxes have been considered hugely important in D.C. political circles — and maybe once they we

COVID-19 has provided a vivid reminder of the power of biological threats. But the threat doesn't come from natural sources alone. Weaponized contagious diseases — which were abandoned by the United States, but developed in large numbers by the Soviet Union, right up until its collapse — have the potential to spread globally and kill just as many as an all-out nuclear war. For five years today’s guest — Andy Weber — was the US Assistant Secretary of Defense responsible for biological and other weapons of mass destruction. While people primarily associate the Pentagon with waging wars, including most within the Pentagon itself, Andy is quick to point out that you can't have national security if your population remains at grave risk from natural and lab-created diseases. Andy's current mission is to spread the word that while bioweapons are terrifying, scientific advances also leave them on the verge of becoming an outdated technology. Links to learn more, summary and full transcript. He thinks there is

Brian Christian is a bestselling author with a particular knack for accurately communicating difficult or technical ideas from both mathematics and computer science. Listeners loved our episode about his book Algorithms to Live By — so when the team read his new book, The Alignment Problem, and found it to be an insightful and comprehensive review of the state of the research into making advanced AI useful and reliably safe, getting him back on the show was a no-brainer. Brian has so much of substance to say this episode will likely be of interest to people who know a lot about AI as well as those who know a little, and of interest to people who are nervous about where AI is going as well as those who aren't nervous at all. Links to learn more, summary and full transcript. Here’s a tease of 10 Hollywood-worthy stories from the episode: • The Riddle of Dopamine: The development of reinforcement learning solves a long-standing mystery of how humans are able to learn from their experience. • ALVINN: A

I suspect today's guest, Lewis Bollard, might be the single best person in the world to interview to get an overview of all the methods that might be effective for putting an end to factory farming and what broader lessons we can learn from the experiences of people working to end cruelty in animal agriculture. That's why I interviewed him back in 2017, and it's why I've come back for an updated second dose four years later. That conversation became a touchstone resource for anyone wanting to understand why people might decide to focus their altruism on farmed animal welfare, what those people are up to, and why. Lewis leads Open Philanthropy’s strategy for farm animal welfare, and since he joined in 2015 they’ve disbursed about $130 million in grants to nonprofits as part of this program. This episode certainly isn't only for vegetarians or people whose primary focus is animal welfare. The farmed animal welfare movement has had a lot of big wins over the last five years, and many of the lessons anima