This Week In Pediatric Oncology

In this episode Dr. Timothy Cripe and Dr. Brenda Weigel are joined by FDA's Dr. Nicole Drezner, pediatric oncologist and the Deputy Division Director of the Division of Oncology 2 who led the FDA review and publication on the approval of DFMO. Listen in on the discussion surrounding the historic approval of DFMO, the first ever oncology drug approved in the setting to prevent relapse using an external control instead of randomization.

Dr. Luca Szalontay,  Assistant Professor of Pediatrics at Columbia University Medical Center, discusses the work of Columbia's Initiative for Drug Delivery Innovation which is exploring new treatments for pediatric brain tumors utilizing Convection Enhanced Delivery and Focused Ultrasound. This initiative has launched a new clinical trial using Focused Ultrasound for patients with  progressive diffuse midline glioma (DMG)

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/ACFprGG10M0 In this episode, our host, Dr. Timothy Cripe from Nationwide Children’s Hospital, is joined by Dr. Seth Rotz - pediatric hematologist/oncologist and the Director of the Fertility Preservation Program at the Cleveland Clinic in Cleveland, Ohio. Listen in as they discuss Dr. Rotz’s career & specialty in fertility preservation for cancer patients: how he got into the field, what was needed to start the program, & the process and risks associated with oncofertility. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/jj3wJU0G7GI Listen in as our hosts, Dr. Tim Cripe & Dr. Brenda Weigel, are joined by Al Gustafson, from The Swifty Foundation, and Dr. Angela Waanders, from Lurie Children's Hospital of Chicago, to discuss the "Gift from a Child" program. This program is led by The Swifty Foundation & helps advocate and educate about post mortem pediatric brain tissue donations. Al & Dr. Waanders discuss the genesis of the program, what the program entails, as well as the benefits of tissue donations to empowering research. To learn more about "Gift from a Child", please visit: https://www.giftfromachild.org/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

Listen in & join the TWiPO team in this special live recorded episode. Our host, Dr. Tim Cripe, along with his Nationwide Children’s Hospital colleagues, Dr. Ryan Roberts, Dr. Elaine Mardis & Dr. Katherine Miller, are joined by Dr. Trevor Pugh, who is a clinical laboratory geneticist from the University of Toronto in Canada. Tune in as they all discuss Dr. Pugh’s specialty in genomics & his recent work regarding the early identification of cancers in patients with Li Fraumeni Syndrome.  To learn more about this study, visit https://www.medrxiv.org/content/10.1101/2022.10.07.22280848v1.full.pdf ----more---- ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/yyQ08ny_hDU Join our host, Dr. Timothy Cripe from Nationwide Children's Hospital, as he’s joined with Dr. Jim Geller from Cincinnati Children’s Hospital to discuss his expertise in pediatric liver cancer - hepatoblastoma. In this episode, we are also specially joined by Kelly & Jessica Woolwine as they tell their story of how they navigated the hepatoblastoma landscape to seek treatment for their daughter, Charlotte. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Z1D-7i4oy1s   Our host, Dr. Timothy Cripe from Nationwide Children's Hospital, is joined by Dr. Martin McCabe from the University of Manchester to discuss the results of the rEECur trial. The rEECur trial is an international randomized trial conducted on recurrent and primary refractory Ewing sarcoma patients. Dr. McCabe leads a discussion on the genesis of rEECur, what it entailed & what was learned from conducting this trial.   To learn more about this trial, please visit https://www.manchester.ac.uk/discover/news/study-identifies-best-treatment-for-rare-childhood-cancer/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/oR0KN5VFDVc Tune in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Garrett Brodeur to discuss his expertise in genetic predispositions in childhood cancer. Dr. Brodeur is the Director of the Pediatric Cancer Predisposition Program at the Children’s Hospital of Philadelphia (CHOP) - and listen in as he discusses his journey leading up to cancer predisposition, what the program entails, as well as the process of screening & surveillance protocols. To learn more about this program, please visit https://www.chop.edu/centers-programs/hereditary-cancer-predisposition-program ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/SvTprrL8wnY This Week in Pediatric Oncology #105 - January 3, 2023 Happy New Year from the TWiPO team! We are opening up this new year with an episode on building a pediatric cancer disease community. Our host, Dr. Timothy Cripe from Nationwide Children's Hospital, with special co-host, Donna Ludwinski from Solving Kids' Cancer, is joined by Ann Graham - Executive Director & Founder of MIB Agents. Listen in as they discuss Ann's personal cancer journey, how it spearheaded her own advocacy efforts, starting MIB Agents & their role in advocating within the childhood cancer research landscape. To learn more about MIB Agents, you can visit https://www.mibagents.org/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/41kwZNhrBBc This Week in Pediatric Oncology #104 - December 13, 2022 In this episode, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Joshua Schiffman - CEO & Co-Founder of PEEL Therapeutics, Inc. Dr. Schiffman’s own personal childhood cancer journey paved his way into the pediatric cancer field. Listen in as he discusses the formation of PEEL, their research work utilizing nanoparticles & nanotechnology, and the opportunities/challenges that are in PEEL’s future. To learn more about PEEL Therapeutics, Inc, please visit https://peeltx.com/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/SkyYLIZxQWA This Week in Pediatric Oncology #103 - November 30, 2022 Join us as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Roger Packer from Children’s National Hospital in Washington DC. Dr. Packer is the Senior Vice President of the Center for Neurosciences and Behavioral Medicine at Children’s National, which is introducing a low-intensity focused ultrasound (LIFU) therapy. Listen in as Dr. Packer discusses what LIFU is and the exciting new techniques and technologies behind it. To learn more, you can visit https://childrensnational.org/news-and-events/childrens-newsroom/2022/a-pediatric-brain-tumor-first-opening-the-blood-brain-barrier-to-deliver-targeted-therapies ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/inNQc6x9Jy8 This Week in Pediatric Oncology #102 - November 10, 2022 Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined again by Dr. Douglas Hawkins - who is the current Chair of the Children’s Oncology Group (COG). They discuss in depth the findings of a presented published paper regarding the inequities of childhood cancer outcomes based on external socioeconomic factors such as neighborhood and household poverty. To read the full paper, visit https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7936051&blobtype=pdf ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/qVMiwnfVQZY Tune in as our hosts, Dr. Tim Cripe & Dr. Brenda Weigel, are joined by Dr. Will Parsons who is the Co-Director of the Brain Tumor Program at Texas Children's Hospital in Houston, TX. In this episode, Dr. Parsons discusses the background & purpose behind the NCI Pediatric MATCH Trial, the current status of the trial itself, and how the data can be used to benefit investigations moving forward. To learn more about the Pediatric MATCH Trial, you can go to https://childrensoncologygroup.org/pediatricmatch ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/8Lj3uFHWo60 Happy 100th Episode to the This Week in Pediatric Oncology Podcast! In this special milestone episode, our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Scott Kennedy & Donna Ludwinski from Solving Kids' Cancer to reminisce on the history & creation of TWiPO and talk about their favorite podcast episodes from over the years. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/bDbtses4w2E Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Samuel Volchenboum who is an Associate Professor of Pediatrics from the University of Chicago. Dr. Volchenboum spearheaded an international effort through two data platforms called the Pediatric Cancer Data Commons (PCDC) & GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes). Listen in as he explains the importance behind these two platforms, as well as the challenges and barriers to data collaboration.   To learn more about the Pediatric Cancer Data Commons, you can visit http://commons.cri.uchicago.edu To learn more about GEARBOx, you can visit http://gearbox.pedscommons.org ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/FBgbCA6TZK4 Listen in as our host, Dr. Timothy Cripe, is joined by Dr. Jonathan Finlay to discuss his acclaimed & reputable career within the pediatric cancer landscape. Dr. Finlay reflects on his distinguished journey including how he got into pediatric immunology, how the field has evolved throughout his medical career, his views on exciting technologies & strategies, and how his personal experience as a patient influenced his position and mindset as a physician. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/5TYFsjh91Tw Listen in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Robbie Majzner - an Assistant Professor of Pediatrics in the Division of Hematology and Oncology at Stanford University's School of Medicine. Dr. Majzner goes into great detail about his recent clinical trial on GD2-CAR T cell therapy for H3K27M-mutated Diffuse Midline Gliomas - the findings, the process, and what the future holds. You can read more about Dr. Majzner's study here: https://www.nature.com/articles/s41586-022-04489-4 Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors.    Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/rFd4Fwa_XVg Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids’ Cancer’s patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.   You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111   Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments. You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast