Foamcast - Emergency Medicine Core Content

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* We review the evidence, to date, on convalescent plasma for the treatment of COVID-19. This includes 3 randomized trials, as well the US experience with >35,000 patients treated with convalescent plasma, a noncontrolled study by Joyner et al [pre-print]. Show notes (references/graphics): FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* We review Spinner et al in JAMA 2020, an open label trial of remdesivir 5 days vs remdesivir 10 days vs 'standard of care' for the treatment of #COVID19 Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust

 We review the Ascorbic Acid, Corticosteroids, and Thiamine in Septic Shock (ACTS) Trial by Moskowitz et al in JAMA Show notes: FOAMcast.org Thanks for listening! Jeremy Faust and Lauren Westafer

We review the AAAAI 2020 anaphylaxis guideline (Shaker et al) A lightening review of anaphylaxis, follow by a discussion of biphasic reaction and the role of steroids and antihistamines Thanks for listening, Jeremy Faust and Lauren Westsafer

Introducing a new series of quick, spoonfed literature updates, 1 article at a time In this episode we review a new trial by Warren et al on antacids versus antacids with lidocaine for epigastric pain and dyspepsia Show notes and references at FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* We review the RECOVERY trial results on hydroxychloroquine for COVID-19 [pre-print by Hornby et al] Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* We review the RECOVERY trial results on dexamethasone for COVID-19 [pre-print by Hornby et al] Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* We explore effects of sterilization and re-use on N95s and KN95s efficiency and fit Sterilization of N95s and KN95s with Hydrogen Peroxide and Chlorine Dioxide (Cai et al) Extended use/reuse of N95 and fit test failure (Degesys et al)  Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded June 19, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* In this episode we discuss data on when SARS-CoV-2 began being detected in US communities  (Jorden et al)   Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded June 9, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* In this episode we discuss some of the mental health ramifications of COVID-19 and the lockdowns: US ED visits for mental health (Smalley et al) Mental health of children during lockdown Xie et al Psychological distress in US adults (McGinty et al) Mood and violence in Chinese interns (Li et al) Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded June 9, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* In an update to the Convalsecent plasma episode we now cover the first RCT on the topic, Li et al Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded June 4, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews a study published by Mehra et al in the Lancet with concerning methods and data anomalies, leading to the possibility and likelihood of falsified data. This came to light after an open letter by Watson et al  detailing major issues. The Lancet issued a correction, which did not address many of the major issues and resulted in significant changes to Table S3 in the supplement. Concerningly, this group also authored the NEJM study on ACE-I/ARBs in COVID-19.  Note: This is an evolving story Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded June 1, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews a study published by Goldman et al dissecting a study on remdesivir - 5 day vs 10 day course. Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 30, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews a study published by Wang et al that received incredible press coverage for touting benefits of mask wearing in one's own home....if it started prior to symptoms. This study is problematic, and we discuss why. Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 29, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews the NIAID trial, ACTT-1, on remdesivir vs placebo (Beigel et al) Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 23, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews an article by Groß et al that demonstrates SARS-CoV-2 RNA can be found in breastmilk Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 22, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19. *Our understanding of COVID-19 is rapidly developing and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode reviews an article by Peyrony et al examining the performance of symptoms, physical exam findings, and ultrasound on the probability of COVID-19. We also go into a bit of an interlude on likelihood ratios Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 22, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19, as literature develops. *Things change frequently and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode is a literature potpourri  Outcomes in pregnancy (Knight et al - pre-print). Are EMS calls for strokes and STEMIs down during the pandemic? Holmes et al More pediatric hyperinflammatory /Kawasaki-esque cases from Italy Verdoni et al More Kawasaki Disease in Paris. (Toubiana et al) Aerosol boxes for intubation (Begley et al) Genomic sequencing reveals healthcare associated clusters (Meredith et al) Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 15, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19, as literature develops. *Things change frequently and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode discusses We interrupt our normal FOAMcast episodes to bring you updates from COVID-19, as literature develops. *Things change frequently and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode discusses Pediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19 , including the study published in the Lancet by Riphagen et al Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 6, 2020 Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 9, 2020

We interrupt our normal FOAMcast episodes to bring you updates from COVID-19, as literature develops. *Things change frequently and this may be out of date in days/weeks. So, check back for updates/fact check what you hear* This episode discusses convalescent plasma, specifically a recent systematic review by Rajendran et al Shen et al Zhang et al Ye et al Ahn et al Duan et al Biegel et al (influenza A RCT) Show notes: FOAMcast.org Thanks for listening, Lauren Westafer and Jeremy Faust *Recorded May 6, 2020